![]() It has been modified for use in autoanalyzers and generally gives relatively accurate results. The diacetyl, or Fearon, reaction develops a yellow chromogen with urea, and this is quantified by photometry. There are two general methods for the measurement of urea nitrogen. Most of those in current use are automated and give clinically reliable and reproducible results. Multiple methods for analysis of BUN and creatinine have evolved over the years. For the adult female, with her generally lower muscle mass, the normal range is 0.5 to 1.1 mg/dl, or 44 to 97 μmol/L by the enzymatic method. For the adult male, the normal range is 0.6 to 1.2 mg/dl, or 53 to 106 μmol/L by the kinetic or enzymatic method, and 0.8 to 1.5 mg/dl, or 70 to 133 μmol/L by the older manual Jaffé reaction. The normal serum creatinine ( sCr) varies with the subject's body muscle mass and with the technique used to measure it. In contrast, the rugged rancher who eats in excess of 125 g protein each day may have a normal BUN of 20 mg/dl. Her higher glomerular filtration rate (GFR), expanded extracellular fluid volume, and anabolism in the developing fetus contribute to her relatively low BUN of 5 to 7 mg/dl. A BUN of 15 mg/dl would represent significantly impaired function for a woman in the thirtieth week of gestation. ![]() The range is wide because of normal variations due to protein intake, endogenous protein catabolism, state of hydration, hepatic urea synthesis, and renal urea excretion. The normal range of urea nitrogen in blood or serum is 5 to 20 mg/dl, or 1.8 to 7.1 mmol urea per liter. The BUN, then, is roughly one-half (28/60 or 0.446) of the blood urea. In Europe, the whole urea molecule is assayed, whereas in the United States only the nitrogen component of urea (the blood or serum urea nitrogen, i.e., BUN or SUN) is measured. Both are relatively small molecules (60 and 113 daltons, respectively) that distribute throughout total body water. Creatinine is the product of muscle creatine catabolism. Urea is the primary metabolite derived from dietary protein and tissue protein turnover. 42x+0.30, r=0.45, p<0.1).Urea and creatinine are nitrogenous end products of metabolism. However the correlation of serum creatinine level between the newborn infants and the mothers was statistically non-significant (Y=0. ![]() 5) The correlation of serum BUN level between the newborn infants and the the mothers was statistically significant(Y=0.42x+5.27, r=0.74, p<0.05). In comparison of the mean serum creatinine level between the premature and normal full-term infants, no significant differences were observed. Mean serum creatinine level between the normal full-term infants and their mothers, the mean serum creatinine level of the mothers was significantly higher than that level of their newborn infants(p<0* 05).Ĥ)The mean serum creatinine level of cord blood in 15 premature infants was 0.46☐.28 mg/dl and that level in 15 their mothers was 0.45☐.30 mg/dl. 3)The mean serum creatinine level of cord blood in 42 normal full-term infants was 0.55 ☐.24 mg/dl and that level in 42 their mothers was 0.66☐.26 mg/dl. In comparison of the mean serum BUN level between the normal full-term and premature infants, no significant differences were observed. 2)The mean serum BUN level of cord blood in 15 premature in fants was 11.30±5.21 In comparison of the mean serum BUN level between the normal full-term and their mothers, no significantĭifferences were observed. The following results were obtained 1)The mean serum BUN level of cord blood in 42 normal full-term infants was 9.67+ 3.42 mg/dl and that level in 42 their mothers was 9.81±5.20 mg/dl. ![]() USA) and serum BUN levels were determined by the urease method (A-Gent BUN reagent, Abbott Laboratories Diagnostic Division, USA). Serum creatinine levels were determined by the method using picric acid(Gilchem creatinine reagent, Gilford Diagnostics, Authors determined the serum creatinine and blood urea nitrogen (BUN) levels of cord blood in 57 newborn infants(42 normal full-term and 15 premature infants) with gestational age of 28 to 42 weeks and their mothers at delivery. The concept of renal function in the neonate has been that the developing kidney is immature and that glomerular and tubular functions are low for body size as compared with the adult. Journal of the Korean Pediatric Society 1985 28(8):741-750.Ī Study on Serum Creatinine and BUN Levels in Newborn Infants.ĭepartment of Pediatrics, College of Medicine, Chosun University, Kwang ju,Korea ![]()
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